RNA Details
Disease Name
nephritis interstitia
Tissue
kidney
RNA Symbol
mir-376b
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
dual-luciferase reporter assay; MTT assays; flow cytometery etc.
Target
ATG5
Pathway
NA
PubMed ID
Title
Inhibition of microRNA-376b Protects Against Renal Interstitial Fibrosis via Inducing Macrophage Autophagy by Upregulating Atg5 in Mice with Chronic Kidney Disease
Year
2018
Function
miR-376b downregulation promotes macrophage autophagy to relieve renal interstitial fibrosis (RIF) by negatively regulating Atg5 in mice with chronic kidney disease (CKD).